Genetic susceptibility to pulmonary tuberculosis in Cambodia - 22/08/11
Abstract |
We have studied the risk of progression to active pulmonary tuberculosis (TB) among a population of Cambodian rural poor suffering from one of the highest global incidences of TB. Together with a community-based TB program, we have established a research partnership that has demonstrated the association of a particular HLA binding motif and progression to active pulmonary TB. We have also shown that candidate gene polymorphisms are ethnic specific and unique in Cambodia and are likely markers for as yet unidentified disease susceptibility and resistance loci. We have also uncovered a high incidence of antigen-specific anergy to purified protein derivative among patients with active pulmonary TB and have correlated this with an expansion of immunosuppressive IL-10 producing T cells and other impaired T cell responses to mycobacterial antigens. These experiments lend insight into TB susceptibility and the molecular mechanisms of antigen-specific anergy. Moreover, they demonstrate that a partnership between TB cure and scientific discovery is possible in even the most impoverished settings.
Le texte complet de cet article est disponible en PDF.Keywords : Genetic susceptibility, HLA, Candidate gene polymorphisms, Tuberculosis, Cambodia
Plan
![]() | Manuscript based upon lecture given at the University of Malaysia Symposium I Tuberculosis and Leprosy: Potential Novel Drugs and Vaccines Against Mycobacterium, 3–5 July 2002, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia. |
![]() ![]() | Sources of support: NIH (HL59838). Informed written consent was obtained from all patients and control individuals. This study was approved by the Center for Blood Research Institutional Review Board. |
Vol 84 - N° 1-2
P. 76-81 - 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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