Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines - 22/08/11
Abstract |
Genetic systems that allow mycobacterial genomes to be mutagenized in a targeted or random fashion have provided the means for developing new tools for the diagnosis, prevention and treatment of tuberculosis by allowing potential targets to be identified and validated. In this review, we highlight key historical developments in the field of mycobacterial genetics, which have yielded the powerful repertoire of genetic tools that are now in hand and provide examples that illustrate their use in exploring specific aspects of mycobacterial metabolism.
Le texte complet de cet article est disponible en PDF.Keywords : Mycobacterium, Tuberculosis, Gene knockout, Transposon, Mycobacteriophage, Target validation
Plan
Vol 84 - N° 1-2
P. 63-75 - 2004 Retour au numéro
Article précédent
- Susceptibility of Mycobacterium tuberculosis to isoniazid and its derivative, 1-isonicotinyl-2-nonanoyl hydrazine: investigation at cellular level
- Suriyati Mohamad, Pazilah Ibrahim, Amirin Sadikun
- Genetic susceptibility to pulmonary tuberculosis in Cambodia
- Anne E Goldfeld
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