No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis - 22/08/11
Corresponding author. Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Tel.: +81 3 58413692; fax: +81 3 5802 2907.summary |
Interferon regulatory factor 1 is a transcription factor involved in initiating a vigorous Th1 response during Mycobacterium tuberculosis infection. Therefore, we considered it as a possible candidate gene for certain polymorphisms to confer susceptibility to develop clinical tuberculosis. However, all polymorphisms with minor allele frequencies higher than 5% and haplotype frequencies in two Southeast Asian populations (Indonesian and Vietnamese) turned out not to be associated with pulmonary tuberculosis.
Le texte complet de cet article est disponible en PDF.Keywords : Tuberculosis, Interferon regulatory factor 1 (IRF1)
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Vol 89 - N° 1
P. 71-76 - janvier 2009 Retour au numéro
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