We describe the use of an ice-cold solution of Ringer's lactate with additives to ameliorate ischemia-reperfusion injury and avoid renal failure in a child with bilateral Wilms tumor requiring nonanatomic, hilar resection that would leave the patient with marginal renal parenchyma postoperatively. The adequate renal function afforded by the procedure avoided the possible need for dialysis and allowed the resection area to be irradiated to prevent tumor recurrence before eventual renal transplantation.