A review of the prognostic factors in patients with recurrence after liver resection for hepatocellular carcinoma - 22/08/11
, Takamichi Saito, M.D., Yoichi Matsui, M.D., Yoichiro Uchida, M.D., Morihiko Ishizaki, M.D., Yasuo Kamiyama, M.D.
Corresponding author. Tel.: +81-72-804-0101, ext. 56130; fax: +81-72-804-0170.Abstract |
Background |
Liver transplantation achieves better results when hepatocellular carcinoma fits the Milan criteria. This study investigated predictors of recurrent hepatocellular carcinoma exceeding the Milan criteria.
Methods |
Among 285 patients with hepatocellular carcinoma fitting the Milan criteria who underwent curative resection, 143 patients suffered initial recurrence (92 had tumors fitting the criteria) and 71 patients suffered a second recurrence (40 conforming tumors).
Results |
Survival after hepatectomy was significantly worse when initial recurrence was nonconforming. Similarly, survival after initial recurrence was significantly worse when the second recurrence was nonconforming. A preoperative increase of protein induced by vitamin K absence/antagonist II, a tumor diameter of 3 cm or greater, age of 65 years or younger, and intraoperative blood transfusion increased the risk of nonconforming initial recurrence.
Conclusions |
Liver transplantation should be considered initially for younger patients with hepatocellular carcinoma fitting the Milan criteria, larger tumors, and an increase of protein induced by vitamin K absence/antagonist II.
Le texte complet de cet article est disponible en PDF.Keywords : Hepatocellular carcinoma, Hepatic resection, Milan criteria, Liver transplantation
Plan
Vol 193 - N° 4
P. 431-437 - avril 2007 Retour au numéro
Article précédent
- Laparoscopic liver resection assisted with radiofrequency
- Philippe Bachellier, Ahmet Ayav, Madhav Pai, Jean-Christopher Weber, Edoardo Rosso, Daniel Jaeck, Nagy A. Habib, Long R. Jiao
- Two-phase scintigraphy with technetium 99m–sestamibi in patients with hyperparathyroidism due to chronic renal failure
- Maria A. Muros, Juan Bravo Soto, José M. López Ruiz, Mariano Rodríguez-Portillo, Angel Ramírez Navarro, María Bellón Guardia, Fernando Perán, Jose M. Llamas-Elvira
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?