Stepwise sequential screening for fetal aneuploidy - 22/08/11
Résumé |
Objective |
The purpose of this study was to evaluate stepwise sequential screening for fetal aneuploidy.
Study Design |
Women who received first-trimester screening were also offered second-trimester tests with second-trimester risks that were based on both sets of markers. Screen-positive rates, use of second-trimester testing and invasive testing, sensitivity, and changes in risks were evaluated.
Results |
Of 1528 women who received first-trimester screening, 133 women (8.7%) had an indication for invasive testing that was based on first-trimester results alone; 1173 women (76.8%) received second-trimester tests, which reduced the net number of women with an indication for invasive testing to 105 (6.9%). In unaffected pregnancies, the addition of the second-trimester testing reduced the median Down syndrome risk from 1:2368 to 1:10,301. Six of 10 chromosome abnormalities (60%) were identified by first-trimester screening, and 9 of 10 chromosome abnormalities (90%) were identified by sequential screening.
Conclusion |
Sequential screening can be introduced successfully into clinical practice, is effective, and can reduce the number of invasive tests that are performed.
Le texte complet de cet article est disponible en PDF.Key words : amniocentesis, chorionic villus sampling, Down syndrome, prenatal screening, trisomy 18
Plan
| Cite this article as: Benn PA, Campbell WA, Zelop CM, Ingardia C, Egan JFX. Stepwise sequential screening for fetal aneuploidy. Am J Obstet Gynecol 2007;197:312.e1-312.e5. Reprints not available from the authors. |
Vol 197 - N° 3
P. 312.e1-312.e5 - septembre 2007 Retour au numéro
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