A semiautomated ultrasound border detection program that facilitates clinical measurement of ultrasound carotid intima-media thickness - 21/08/11
, Claudia E. Korcarz, DVM, RDCS *, Maureen E. Mays, MD, MS *, Pamela S. Douglas, MD *, Mari Palta, PhD †, Hongling Zhang, MS †, Tamara LeCaire, MS †, Diane Paine, MED, RDCS §, David Gustafson, PhD §, Liexiang Fan, PhD §
Reprint requests: James H. Stein, MD, Department of Medicine, Section of Cardiovascular Medicine, University of Wisconsin Medical School, 600 Highland Avenue, G7/341 CSC (MC 3248), Madison, WI 53792Résumé |
We have developed a novel, semiautomated carotid intima-media thickness (CIMT) border detection program (AUTO) and evaluated its measurement reproducibility and accuracy. Images from 6 carotid segments were acquired in 50 subjects, for a total of 300 segments. Mean and maximum CIMT values were measured blindly at a reference (REF) lab and in duplicate by experienced (EXP) and novice (NOV) readers using manual (MAN) and AUTO methods. Coefficients of variation for AUTO measurements of mean (3.2%) and maximum (4.1%) CIMT were low, and the AUTO method improved the NOV reader’s reproducibility. Compared with the REF lab, mean (0.012 ± 0.006 mm) and maximum (0.144 ± 0.006 mm) CIMT biases were small and equivalent to those of the REF lab (P < .001). The AUTO method shortened reading times by 35% to 46% (P < .001). We conclude that our novel AUTO CIMT measurement program improved reproducibility and was accurate. Compared with MAN tracing, the AUTO method agreed better with the REF lab and decreased reading time.
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| Supported by a grant from Siemens Medical Solutions. Dr. Stein was supported by the National Center for Research Resources (grant K23 RR16176), receives research support from Siemens Medical Solutions, and is a consultant to Camtronics Medical Systems and Sonosite, Inc. Dr. Stein, Dr. Palta, Ms. Zhang, and Ms. LeCaire also received funding from the National Heart, Lung, and Blood Institute (grant R01 HL62897). Dr. Mays was supported by National Institutes of Health National Service Award T32 HL07936, from the University of Wisconsin-Madison Cardiovascular Research Center. Ms. Paine, Dr. Gustafson, and Dr. Fan are employees of Siemens Medical Solutions. |
Vol 18 - N° 3
P. 244-251 - mars 2005 Retour au numéro
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