Skin cancer in organ transplant recipients: Effect of pretransplant end-organ disease - 21/08/11
Correspondence to: Clark C. Otley, MD, Division of Dermatologic Surgery, Mayo Clinic, 200 First St SW, Rochester, MN 55905.Rochester, Minnesota; Richmond, Virginia; and Tucson, Arizona
Abstract |
Background |
Solid organ transplant recipients are at increased risk for posttransplant neoplasms.
Objective |
Our purpose was to determine whether various diseases causing end-organ failure are associated with different degrees of risk of skin cancer development after transplantation.
Methods |
The Organ Procurement and Transplantation Network/United Network for Organ Sharing Transplant Tumor Registry was searched for the incidence of skin cancer among kidney, liver, and heart transplant recipients in the United States between 1996 and 2001. Multivariate analysis was used to determine the association between disease diagnosis and posttransplant skin cancer.
Results |
Transplant recipients with specific pretransplant diseases, such as polycystic kidney disease and cholestatic liver disease, were at increased risk for skin cancer. Patients with diabetes mellitus had a lower incidence of skin cancer after kidney transplantation.
Limitations |
The study had only a brief follow-up period, indirect assessment of photodamage, and possible underreporting.
Conclusion |
Transplant recipients with a history of certain diseases warrant intensive skin cancer surveillance and strict sun-protective practices.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CI, CYA, MMF, NMSC, OPTN/UNOS, PRA, RR, TAC
Plan
| Funding sources: Supported by a Cutting Edge Research grant from the American Society for Dermatologic Surgery and in part by Health Resources and Services Administration contract 231-00-0115. Conflicts of interest: None identified. The content of this article is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. Reprints not available from the authors. |
Vol 53 - N° 5
P. 783-790 - novembre 2005 Retour au numéro
Article précédent
- Dermal matrix remodeling after nonablative laser therapy
- Jeffrey S. Orringer, John J. Voorhees, Ted Hamilton, Craig Hammerberg, Sewon Kang, Timothy M. Johnson, Darius J. Karimipour, Gary Fisher
- Board Certification in Dermatopathology
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?