Long-term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens the collagen band in papillary dermis - 21/08/11
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Ann Arbor, Michigan
Abstract |
Background |
Risk of photocarcinogenesis and the relevance of collagen in wrinkle effacement are two issues related to prolonged use of retinoic acid (RA) that have not been fully addressed.
Objective |
Our purpose was to investigate the degree of epidermal cellular atypia and the thickness of papillary dermal collagen in photoaging after long-term use of RA.
Methods |
Thirty-four subjects with photoaged skin were treated daily with 0.05% RA for at least 6 months. Epidermal cellular atypia was graded by means of a semiquantitative scale. Thickness of collagen band was measured by using image-analysis software.
Results |
Compared with pretreatment findings, melanocytic and keratinocytic atypia was significantly reduced and the collagen band thickness doubled.
Limitations |
This was an open-label study.
Conclusion |
Improvement in epidermal cellular atypia is consistent with the ability of RA to act as a chemopreventive agent in epithelial carcinogenesis. Prolonged use also significantly increased collagen matrix deposition in dermal repair zones, which most likely contributes to wrinkle effacement by RA.
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Funding source: Supported in part by a grant from Johnson & Johnson Corporation, the Babcock Endowment for Dermatological Research, and the National Institutes of Health (1 K24 AR02159-01 (to S. K.). Conflict of interest: None identified. |
Vol 53 - N° 5
P. 769-774 - novembre 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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