Prorenin Levels in Retinopathy of Prematurity - 21/08/11
, Taiji Nagaoka, MD, PhD a, Fumihiko Mori, MD, PhD a, Taiichi Hikichi, MD, PhD a, Hiromichi Hosokawa, PhD b, Hiroshi Tanaka, PhD c, Yuichi Ishida, PhD d, Fumiaki Suzuki, PhD e, Akitoshi Yoshida, MD, PhD a
Inquiries to Harumasa Yokota, MD, PhD, Department of Ophthalmology, Asahikawa Medical College, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510 JapanRésumé |
Purpose |
To evaluate serum prorenin levels in preterm infants with or without retinopathy of prematurity (ROP).
Design |
Noncomparative retrospective case control study.
Methods |
Serum prorenin levels in children with a gestational age younger than 36 weeks were measured with antibody-activating direct enzyme kinetic assay.
Results |
The mean prorenin concentrations were higher in preterm infants with ROP than in infants without ROP at every time point: from 26 to 30 weeks, 2326 ± 334 μg/ml (mean ± SE [standard error]) (n = 3) and 1164 ± 234 μg/ml (n = 3), respectively (P < .05); from 31 to 35 weeks, 1760 ± 496 μg/ml (n = 10) and 957.1 ± 139 μg/ml (n = 25) (P < .05); from 36 to 40 weeks, 958.2 ± 194.2 μg/ml (n = 23) and 470.1 ± 32.6 μg/ml (n = 67) (P < .01); and from 41 to 45 weeks, 575.8 ± 148.4 (n = 9) and 385.6 ± 47.9 (n = 13), which is not significantly different.
Conclusions |
Prorenin levels in preterm infants can predict which infants will develop ROP.
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Vol 143 - N° 3
P. 531-533 - mars 2007 Retour au numéro
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