Ultrasonic Biophysical Measurements in the Normal Human Fetus for Optimal Design of the Monolithic Fetal Pacemaker - 21/08/11

Doi : 10.1016/j.amjcard.2005.01.066

Evgueni Fayn, MD ^a,^b, Howard A. Chou, PhD ^b,^d, DaeGyun Park, MD, PhD ^b, Daniel H. Zavitz, MSc ^b, Bettina F. Cuneo, MD ^d, Vicki L. Mahan, MD ^d,^f, Mehmet Guleçyuz, MD ^d, Letitia Curran, RDMS ^e, David Lipson, PhD ^j, Edmond W. Quillen, PhD ^h, Boris M. Petrikovsky, MD, PhD ^g, Marc Ovadia, MD ^b,^c,^d,^i,^k,^l,^⁎
^a Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois
^b Department of Pediatrics, University of Illinois College of Medicine, Chicago, Illinois
^c Department of Internal Medicine (Cardiology), Michael Reese Hospital and Medical Center, Chicago, Illinois
^d The Heart Institute for Children, Park Ridge, Illinois
^e The Lutheran General Hospital and Hope Children's Hospital, Park Ridge, Illinois
^f Department of Surgery (Cardiothoracic Surgery), Children's Hospital of Buffalo, SUNY at Buffalo, Buffalo, New York
^g Department of Obstetrics and Gynecology, Nassau University Medical Center, East Meadow, New York
^h Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois
ⁱ Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois
^j Department of Bioengineering, Cornell University, Ithaca, New York
^k Department of Internal Medicine (Cardiology), Mount Sinai Hospital and Medical Center, Chicago, Illinois
^l Department of Pediatrics, University of Chicago, Pritzker School of Medicine, Chicago, Illinois

Dr. Ovadia's address is: Department of Pediatrics, University of Chicago, Pritzker School of Medicine, Comer Children's Hospital, Rm C-102B, 5721 S Maryland Ave, Chicago, Illinois 60637

Résumé

Ultrasound measurements, including xiphoid-to-pericardial distance and deployment angle, were made on human fetuses as a function of gestational age for the purpose of assessing the likelihood of 3 failure modes of a monolithic fetal pacemaker, including primary positioning failure due to device length and secondary dislodgement failure due to somatic growth. The small variation of the measurements over the gestational age range relevant to device implantation for the major indications of the device (for complete heart block complicated by hydrops and for bradycardia risk after fetal surgery or intrauterine intervention) predicts a small likelihood of these failure modes.

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This study was supported by the National Institutes of Health, Bethesda, Maryland (NIH HHS 1R43HL67520-01).

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Vol 95 - N° 10

P. 1267-1270 - mai 2005 Retour au numéro

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Ultrasonic Biophysical Measurements in the Normal Human Fetus for Optimal Design of the Monolithic Fetal Pacemaker - 21/08/11

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