Effect of triiodothyronine on gene transcription during cardiopulmonary bypass in infants with ventricular septal defect - 21/08/11
Doi : 10.1016/j.amjcard.2004.11.039
Sara Danzi, PhD a, Irwin Klein, MD a, Michael A. Portman, MD b, ⁎ 
a Division of Endocrinology, Department of Medicine, North Shore University Hospital/New York University School of Medicine, Manhasset, New York
b Division of Cardiology, Department of Pediatrics, University of Washington School of Medicine and Children's Hospital and Regional Medical Center, Seattle, Washington
Dr. Portman's address is: Division of Cardiology, Children's Hospital and Regional Medical Center (4G-1), 4800 Sand Point Way NE, Seattle, Washington 98105-0371Résumé |
We tested the hypothesis that triiodothyronine (T3) supplementation alters gene transcription in the left ventricular myocardium of infants undergoing cardiopulmonary bypass for ventricular septal defect repair. To our knowledge, a novel heteronuclear assay demonstrated for the first time in human heart that rapid change in T3 levels altered the adenine nucleotide translocase-1 transcription rate during cardiopulmonary bypass.
Le texte complet de cet article est disponible en PDF.| Dr. Danzi was supported in part by Grant 0120171T from the American Heart Association Fellowship, Dallas, Texas; and Dr. Portman was supported by Grant FD-R-1971-01 from the US Food and Drug Administration, Rockville, Maryland. |
© 2005
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Vol 95 - N° 6
P. 787-789 - mars 2005 Retour au numéro
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