Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies - 21/08/11
Résumé |
Objective |
The objective of the study was to determine whether blood pressure increases are associated with maternal angiogenic factors in uncomplicated and preeclamptic pregnancies.
Study Design |
Associations of blood pressure increases from mid- to late pregnancy with maternal serum concentrations of soluble fms-like tyrosine kinase receptor (sFlt1), soluble endoglin (sEng), and placental growth factor (PlGF) at delivery were analyzed in 43 uncomplicated and 44 preeclamptic pregnancies.
Results |
In uncomplicated pregnancies, increases in diastolic and mean arterial pressure were inversely associated with PlGF at delivery and positively associated with sEng and sFlt1/PlGF ratio. There were no significant associations between blood pressure increases and angiogenic factor concentrations in preeclampsia.
Conclusion |
These data suggest that angiogenic factors are involved in blood pressure modulation in normotensive pregnancy and are consistent with the hypothesis that angiogenic balance plays a role in maternal breast cancer risk reduction associated with mid- to late blood pressure increases in uncomplicated pregnancies.
Le texte complet de cet article est disponible en PDF.Key words : angiogenic factors, blood pressure, breast cancer, preeclampsia, pregnancy
Plan
| This study was supported by grants from Vitenskapsradet Ullevål universitetssykehus and the Woman and Child Division, Ullevål University Hospital. The Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, and US Department of Health and Human Services also provided funding. |
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| Reprints not available from the authors. |
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| Cite this article as: Troisi R, Braekke K, Harsem NK, et al. Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies. Am J Obstet Gynecol 2008;199:653.e1-653.e10. |
Vol 199 - N° 6
P. null - décembre 2008 Retour au numéro
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