Treatment of intrauterine growth restriction with maternal growth hormone supplementation in sheep - 21/08/11
Reprints: Prof. J. E. Harding, The Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New ZealandRésumé |
Objective |
This study was undertaken to investigate whether maternal growth hormone supplementation in pregnant sheep could reverse intrauterine growth restriction (IUGR) induced by placental embolization.
Study Design |
Animals were randomized into control, intrauterine growth restriction + saline or intrauterine growth restriction + growth hormone (twice daily injections of 0.1 mg/kg growth hormone) groups. Intrauterine growth restriction was induced by twice daily placental embolization between 93 and 99 days' gestation, and treatment was from 100-128 days' gestation (term = 147 days' gestation).
Results |
Embolization reduced fetal growth rate and body weight but increased brain-to-liver weight ratio. Growth hormone treatment significantly increased fetal growth rates and fat deposition, and improved fetal body weight and length, but not liver weight. Growth hormone treatment produced hydranencephalic brain lesions in some fetuses.
Conclusion |
Maternal growth hormone treatment partially reversed intrauterine growth restriction caused by placental insufficiency. However, the possible connection between growth hormone treatment and fetal brain injury requires further investigation
Le texte complet de cet article est disponible en PDF.Key words : brain, fetus, growth hormone, intrauterine growth restriction, sheep
Plan
| This study was funded by the Health Research Council of New Zealand. |
|
| Cite this article as: de Boo HA, Eremia SC, Bloomfield FH, et al. Treatment of intrauterine growth restriction with maternal growth hormone supplementation in sheep. Am J Obstet Gynecol 2008;199:559.e1-559.e9. |
Vol 199 - N° 5
P. null - novembre 2008 Retour au numéro
Article précédent
- Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion
- Funminiyi Ajayi, Nicholas Kongoasa, Thomas Gaffey, Yan W. Asmann, William J. Watson, Alfonso Baldi, Peeyush Lala, Viji Shridhar, Brian Brost, Jeremy Chien
- Effecting the sixth core competency: a project-based curriculum
- Brandy R. Patterson, Kristopher J. Kimball, Julie B. Walsh-Covarrubias, Larry C. Kilgore
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?