Fetal nasal bone status in Chinese women undergoing first-trimester screening for trisomy 21 - 21/08/11
, Lin Wai Chan, MRCOG, Lai Wa Law, MRCOG, Tak Yuen Fung, MRCOG, Tze Kin Lau, MD
Reprints: Daljit Sahota, PhD, Department of Obstetrics and Gynaecology, Prince of Wales Hospital, Shatin, Hong Kong SAR, ChinaRésumé |
Objective |
The objective of the study was to determine the likelihood ratio for trisomy 21 in Chinese fetuses with absent nasal bone (NB) at 11-14 weeks of gestation.
Study Design |
The NB was classified as present or absent in 8101 chromosomally/phenotypically normal or trisomy 21 pregnancies. The effect of crown rump length (CRL), nuchal translucency (NT), maternal age, and fetal karyotype on the incidence of absent NB was examined using logistic regression.
Results |
The NB was successfully examined in 7925 cases (97.8%). The incidence of absent NB in unaffected and trisomy 21 cases were 2.1% (164/7899) and 50% (13/26), respectively. CRL (odds ratio [OR], 0.9; 95% confidence interval [CI], 0.87-0.92), NT (OR, 1.7; 95% CI, 1.4-2.3), and trisomy 21 (OR, 22.3; 95% CI, 8.1-61) were significant independent predictors of likelihood of absent NB. Positive likelihood ratios (LR) for trisomy 21 in Chinese were lower than that of Caucasians for the equivalent CRL and NT measurements.
Conclusion |
Estimated risk for trimsomy 21 in Chinese incorporating nasal bone status should use LRs derived in Chinese rather than Caucasians.
Le texte complet de cet article est disponible en PDF.Key words : Chinese, nasal bone, nuchal translucency, screening, trisomy 21
Plan
| Cite this article as: Leung TY, Sahota D, Chan LW, et al. Fetal nasal bone status in Chinese women undergoing first-trimester screening for trisomy 21. Am J Obstet Gynecol 2008;199:521.e1-521.e5. |
Vol 199 - N° 5
P. null - novembre 2008 Retour au numéro
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