Prenatal psychosocial stress exposure is associated with insulin resistance in young adults - 21/08/11
, Robert Kumsta, PhD a, Irmgard M. Layes, MD a, Edward L. Nelson, MD b, Dirk H. Hellhammer, PhD a, Pathik D. Wadhwa, MD, PhD c, ⁎ 
Reprints: Pathik D. Wadhwa, MD, PhD, Behavioral Perinatology Research Program, University of California, Irvine, 3117 Gillespie Neuroscience Research Facility, Zot Code 4260, Irvine, CA 92697Stefan Wüst, PhD, Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, GermanyRésumé |
Objective |
The objective of the study was to examine the association in humans between maternal psychosocial stress exposure during pregnancy and measures of glucose-insulin metabolism in the adult offspring.
Study Design |
Healthy young adults whose mothers experienced major stressful life events during their pregnancy (n = 36, prenatal stress, PS group, mean age 25 ± 5.14 [SD] years) and a comparison group (n = 22, CG, mean age 24 ± 3.7 [SD] years) underwent an oral glucose tolerance test.
Results |
Glucose levels were not significantly different across the groups; however, prenatally stressed subjects showed significantly elevated 2-hour insulin (P = .01) and C-peptide levels (P = .03). These differences were independent of other major risk factors for insulin resistance, including birth phenotype (birthweight, length of gestation), a family history of diabetes, gestational diabetes, body mass index, proinflammatory state, and smoking.
Conclusion |
Higher insulin responses reflect relative insulin resistance in these prenatally stressed young adults. This study is the first to provide evidence for a link in humans between prenatal psychosocial stress exposure and alterations in glucose-insulin metabolic function.
Le texte complet de cet article est disponible en PDF.Key words : insulin resistance, prenatal stress, psychosocial
Plan
| Cite this article as: Entringer S, Wuest S, Kumsta R, et al. Prenatal psychosocial stress exposure is associated with insulin resistance in young adults. Am J Obstet Gynecol 2008;199:498.e1-498.e7. |
|
| This study was supported in part by Grant WU 324/3-1-3 from the German Research Foundation (to S.W.) and Grants HD-047609, HD-041696, and HD-33506 from the US Public Health Service, National Institutes of Health (to P.D.W.). |
Vol 199 - N° 5
P. null - novembre 2008 Retour au numéro
Article précédent
- Time of delivery and neonatal morbidity and mortality
- Aaron B. Caughey, Adam C. Urato, Kathryn A. Lee, Mari-Paule Thiet, A. Eugene Washington, Russell K. Laros
- Impact of pain level on second-stage delivery outcomes among women with epidural analgesia: results from the PEOPLE study
- Haim A. Abenhaim, William D. Fraser
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?