Clinical Outcome of Patients with Heart Failure and Preserved Left Ventricular Function - 20/08/11
, Donna Zwas, MD a, David Planer, MD a, Tanya Azaz-Livshits, PhD b, Dan Admon, MD a, Chaim Lotan, MD a, Andre Keren, MD a
Requests for reprints should be addressed to Israel Gotsman, MD, Heart Institute, Hadassah University Hospital, POB 12000, Jerusalem, Israel IL-91120Abstract |
Background |
Patients with heart failure have a poor prognosis. However, it has been presumed that patients with heart failure and preserved left ventricular function (LVF) may have a more benign prognosis.
Objectives |
We evaluated the clinical outcome of patients with heart failure and preserved LVF compared with patients with reduced function and the factors affecting prognosis.
Methods |
We prospectively evaluated 289 consecutive patients hospitalized with a definite clinical diagnosis of heart failure based on typical symptoms and signs. They were divided into 2 subsets based on echocardiographic LVF. Patients were followed clinically for a period of 1 year.
Results |
Echocardiography showed that more than one third (36%) of the patients had preserved systolic LVF. These patients were more likely to be older and female and have less ischemic heart disease. The survival at 1 year in this group was poor and not significantly different from patients with reduced LVF (75% vs 71%, respectively). The adjusted survival by Cox regression analysis was not significantly different (P=.25). However, patients with preserved LVF had fewer rehospitalizations for heart failure (25% vs 35%, P<.05). Predictors of mortality in the whole group by multivariate analysis were age, diabetes, chronic renal failure, atrial fibrillation, residence in a nursing home, and serum sodium≤135 mEq/L.
Conclusion |
The prognosis of patients with clinical heart failure with or without preserved LVF is poor. Better treatment modalities are needed in both subsets.
Le texte complet de cet article est disponible en PDF.Keywords : Heart failure, Outcome, Preserved left ventricular function, Survival
Plan
| Funding source: The Louis Chor Memorial Trust Award for research in Cardiac Disease. |
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| Conflict of interest statement for all authors: There is no conflict of interests. |
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| Authorship: The work is original and all authors meet the criteria for authorship, including acceptance of responsibility for the scientific content of the article. All authors had access to the data and a role in writing the article. |
Vol 121 - N° 11
P. 997-1001 - novembre 2008 Retour au numéro
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