Predicting cancer on excision of atypical ductal hyperplasia - 20/08/11
Corresponding author. Tel.: +1-708-327-3433; fax: +1-708-327-3565.Abstract |
Background |
There are no specific histopathologic factors that allow identification of patients with atypical ductal hyperplasia (ADH) who will have cancer on final excision.
Methods |
This was a retrospective study of all patients who had ADH on biopsy followed by excision from 1999 to 2006.
Results |
Fifty-one patients were found to have ADH on core biopsy. Eight (15.7%) patients had invasive carcinoma on surgical excision, 9 (17.5%) had ductal carcinoma-in-situ (DCIS), 21 (41.5%) had ADH, 4 (8%) patients had atypical lobular hyperplasia, and 9 (17.5%) had benign tumors. The grade of atypia on the core biopsy was mild in 13 (25%) patients, moderate in 22 (43%), and marked in 16 (32%). On multivariate analysis of histopathologic factors, the grade of atypia was the only significant variable that predicted a diagnosis of cancer on final surgical excision (P = .001).
Conclusions |
The grade of atypia correlated with the presence of cancer on surgical excision.
Le texte complet de cet article est disponible en PDF.Keywords : Breast cancer, Atypical ductal hyperplasia
Plan
Vol 195 - N° 3
P. 358-362 - mars 2008 Retour au numéro
Article précédent
- Long-term effects on diet after proctocolectomy for ulcerative colitis
- C. Max Schmidt, Chad A. Wiesenauer, James V. Sitzmann
- Melanoma adrenal metastasis: natural history and surgical management
- Elizabeth A. Mittendorf, Sherry J. Lim, Chris W. Schacherer, Anthony Lucci, Janice N. Cormier, Paul F. Mansfield, Jeffrey E. Gershenwald, Merrick I. Ross, Jeffrey E. Lee
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?