Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE - 20/08/11
Reprint requests: Joshua A. Boyce, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Smith Building, Room 626B, 1 Jimmy Fund Way, Boston, MA 02115.Boston, Mass
Abstract |
A case of a girl who presented at age 12 years with idiopathic cold urticaria is described. Her reactions to the cold became progressively more severe over a period of approximately 2 years, despite therapy with H1 antagonists and a type 1 receptor for cysteinyl leukotrienes receptor antagonist. She began to experience systemic symptoms on immersion in ocean water. She was atopic and had moderate persistent asthma. A trial of anti-IgE resulted in complete resolution of her urticaria and its associated manifestations. These findings should prompt a reexamination of the potential pathogenetic role played by IgE and its high-affinity receptor on mast cells in idiopathic cold urticaria.
Le texte complet de cet article est disponible en PDF.Key words : Urticaria, anaphylaxis, mast cells, IgE
Abbreviation used : FCAS
Plan
| Supported by National Institutes of Health grants AI-48802, AI-52353, AI-31599, and HL-36110 and by grants from the Charles Dana Foundation and the Vinik Family Fund for Research in Allergic Diseases. Disclosure of potential conflict of interest: J. A. Boyce has consultant arrangements with Altana and Tanox and is on the speakers’ bureau for Genentech/Novartis, Merck, and GlaxoSmithKline. |
Vol 117 - N° 6
P. 1415-1418 - juin 2006 Retour au numéro
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