Nasal inflammation and personal exposure to fine particles PM2.5 in asthmatic children - 20/08/11
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Paris, France
Abstract |
Background |
Outdoor and indoor air pollutants are suspected to induce harmful effects on respiratory health, raising the question of their involvement in allergic asthma and rhinitis.
Objective |
The potential effect of short-term personal exposure to particulate matter with a diameter of less than 2.5 μm (PM2.5) on nasal inflammation was examined in children living in the Paris area.
Methods |
Forty-one children with allergic asthma and 44 healthy children participated in this study. They were monitored during 48 hours for their personal exposure to PM2.5. At the end of the measurement period, children underwent one nasal lavage. Nasal lavage fluid was investigated for cellular (neutrophils and eosinophils) and soluble (albumin, urea, elastase, ⍺1-antitrypsin, IL-6, and IL-8) mediators.
Results |
Pollutant concentrations did not differ between the 2 groups. In asthmatic subjects, but not in healthy children, personal PM2.5 levels were correlated to nasal percentage of eosinophils and to albumin, urea, and ⍺1-antitrypsin concentrations after adjustment for confounders (age, sex, house dust mites, pollens, cat, environmental tobacco smoke through urinary cotinine, barometric pressure, and respiratory infection).
Conclusion |
The association observed with the percentage of eosinophils supports recent speculations on fine particle involvement in allergic phenotype overexpression.
Clinical implications |
This study highlights the link between personal fine particle exposures and nasal inflammation in asthmatic allergic children living in urban areas. Because the view of united airways is still not completely understood, the question of pulmonary inflammation in such a situation deserves further investigation.
Le texte complet de cet article est disponible en PDF.Key words : Nasal lavage fluid, inflammation, allergy, asthma, eosinophil, children, personal exposure, fine particle, PM2.5
Abbreviations used : DEP, ETS, NAL, NALF, PM, PM2.5, PM10
Plan
Supported by the French research Program on air pollution (PRIMEQUAL/PREDIT) coordinated by the Ministry of Environment. Lydia Nikasinovic received a doctoral grant from Agence de l’Environnement et de la Maîtrise de l’Énergie (Paris, France). Also supported by Assistance Publique-Hôpitaux de Paris (Paris, France) and Laboratoire Novartis (Rueil-Malmaison, France) and Laboratoire MSD (Paris, France). Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest. |
Vol 117 - N° 6
P. 1382-1388 - juin 2006 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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