Molecular regulation of mast cell activation - 20/08/11
Bethesda, MdThis activity is available for CME credit. See page 36A for important information.
Abstract |
The mast cell is a central player in allergy and asthma. Activation of these cells induces the release of preformed inflammatory mediators localized in specialized granules and the de novo synthesis and secretion of cytokines, chemokines, and eicosanoids. The balance of engaging inhibitory and activatory cell-surface receptors on mast cells determines whether the cell becomes active on encountering a challenge. However, recent evidence suggests that, once activated, a mast cell’s response is further regulated by the balance of both positive and negative intracellular molecular events that extend well beyond the traditional role of kinases and phosphatases. These functional responses are also carefully governed by other protein and lipid mediators that determine the rate and extent of the response. Molecules that have adaptor functions, modulate lipids, and provide synergistic signals add to the regulatory complexity. Considerable information has been obtained from the study of the high-affinity receptor for IgE (FcRI), and thus it is the major focus of this review. The unifying theme is that the regulatory steps mentioned herein are required for promoting effective responses while protecting against unwanted inflammatory responses.
Le texte complet de cet article est disponible en PDF.Key words : FcRI, Lyn, Fyn, IgE, mast cell, degranulation
Abbreviations used : Akt/PKB, BMMC, Btk, Csk, DAG, ERK, Gab2, ITAM, ITIM, LAT, MAP, MIST/Clnk, NTAL, PA, PH, PIP3, PI3K, PKC, PLA2, PLD, PLCγ, PTEN, SHIP, SHP-1/2, SphK, S1P, Src PTK
Plan
(Supported by an unrestricted educational grant from Genentech, Inc. and Novartis Pharmaceuticals Corporation) Series editors: William T. Shearer, MD, PhD, Lanny J. Rosenwasser, MD, and Bruce S. Bochner, MD Supported by the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest. |
Vol 117 - N° 6
P. 1214-1225 - juin 2006 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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