Pubertal Changes of Insulin Sensitivity, Acute Insulin Response, and β-Cell Function in Overweight Latino Youth - 20/08/11
Reprint requests: Dr Michael I. Goran, PhD, University of Southern California, Keck School of Medicine, 2250 Alcazar Street, Los Angeles, CA 90089-9008.Abstract |
Objective |
To examine changes in insulin sensitivity (SI), compensatory acute insulin response (AIR), and β-cell function/disposition index (DI) across puberty in overweight Latino boys and girls.
Study design |
Latino children (n = 253) were followed annually for up to 5 years. Longitudinal modeling was used to examine changes in SI, AIR, DI, and fasting and 2-hour glucose and insulin across Tanner stage.
Results |
In boys, SI decreased in early puberty with a recovery by late puberty. The compensatory increase in AIR was appropriate in early maturation, but after Tanner stage 3, AIR declined by more than that predicted from the recovery in SI. For girls, SI decreased in early puberty and across all stages of maturation. In early maturation, there was an appropriate compensatory increase in AIR, but after Tanner stage 3, AIR decreased. Thus, DI deteriorated across puberty in boys and girls.
Conclusions |
In overweight Hispanic youth, compensatory changes in insulin secretion fails after Tanner stage 3 in both sexes, indicating β-cell deterioration during this critical period of development, thus increasing risk for type 2 diabetes.
Le texte complet de cet article est disponible en PDF.Mots-clés : AIR, DI, SI
Plan
| Supported by grants (R01 DK 59211 and M01 RR 00043), the American Diabetes Association, Mentor-Based Postdoctoral Fellowship (F31-DK081276 to C.T.-C. under the sponsorship of M.G.), and the USC Center for Transdisciplinary Research on Energetics and Cancer (U54 CA 116848). The authors declare no conflicts of interest. |
Vol 158 - N° 3
P. 442-446 - mars 2011 Retour au numéro
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