Novel Biomarkers: Help or Hindrance to Patient Care in the Emergency Department? - 20/08/11
Résumé |
Editor's Capsule Summary for Shapiro et al1 What is already known on this topic |
Acute kidney injury is common in severe infection. At present, there are no biomarkers that accurately detect its presence before increase of the creatinine level.
What question this study addressed |
This 661-patient observational study tested the diagnostic performance of neutrophil gelatinase–associated lipocalin (NGAL) to detect acute kidney injury in emergency department patients with suspected infection.
What this study adds to our knowledge |
Plasma concentrations of NGAL greater than 150 ng/dL were 96% sensitive and 51% specific for acute kidney injury occurring within the first 72 hours of hospitalization.
How this might change clinical practice |
These preliminary results should not change clinical practice but suggest that NGAL may be useful for identifying patients at risk for acute kidney injury.
Le texte complet de cet article est disponible en PDF.Plan
| Section editors: Tyler W. Barrett, MD, MSCI; David L. Schriger, MD, MPH |
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| Editor's Note: You are reading the 16th installment of Annals of Emergency Medicine Journal Club. This bimonthly feature seeks to improve the critical appraisal skills of emergency physicians and other interested readers through a guided critique of actual Annals of Emergency Medicine articles. Each Journal Club will pose questions that encourage readers—be they clinicians, academics, residents, or medical students—to critically appraise the literature. During a 2- to 3-year cycle, we plan to ask questions that cover the main topics in research methodology and critical appraisal of the literature. To do this, we will select articles that use a variety of study designs and analytic techniques. These may or may not be the most clinically important articles in a specific issue, but they are articles that serve the mission of covering the clinical epidemiology curriculum. Journal Club entries are published in 2 phases. In the first phase, a list of questions about the article is published in the issue in which the article appears. Questions are rated “novice,” ( |
Vol 56 - N° 1
P. 60-61 - juillet 2010 Retour au numéro
Article précédent
- The Diagnostic Accuracy of Plasma Neutrophil Gelatinase–Associated Lipocalin in the Prediction of Acute Kidney Injury in Emergency Department Patients With Suspected Sepsis
- Nathan I. Shapiro, Stephen Trzeciak, Judd E. Hollander, Robert Birkhahn, Ronny Otero, Tiffany M. Osborn, Eugene Moretti, H. Bryant Nguyen, Kyle Gunnerson, David Milzman, David F. Gaieski, Munish Goyal, Charles B. Cairns, Kenneth Kupfer, Seok-Won Lee, Emanuel P. Rivers
- Save the Beans
- Alice M. Mitchell, Jeffrey A. Kline
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