Pulmonary Adverse Events of Anti-Tumor Necrosis Factor-⍺ Antibody Therapy - 20/08/11
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Abstract |
It is well established that anti-tumor necrosis factor-⍺ (TNF⍺) antibody is an efficacious disease-modifying drug for rheumatoid arthritis and Crohn’s disease. Unfortunately, its long-term use can be associated with ominous pulmonary adverse events, most notably mycobacterial and fungal lung infections. To this end, reactivation of latent tuberculosis infection represents a serious concern of anti-TNF⍺ antibody therapy. Given the anticipated increase in the approved indications for these drugs, community-based physicians should be made aware of these events for implementation of better patient selection for anti-TNF⍺ antibody therapy and initiation of appropriate measures once these adverse events are observed. This review will address this issue by outlining: 1) the role of TNF⍺ in host inflammatory response to injury, particularly during mycobacterial and fungal infections; 2) the salutary effects of anti-TNF⍺ antibody therapy in human diseases; and 3) the ominous pulmonary adverse events associated with these drugs.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, Crohn’s disease, Sarcoidosis, Tuberculosis, Fungi
Plan
This work was supported in part by the American Lung Association, and the American Lung Association of Metropolitan Chicago (G.M.M.), National Institute of Diabetes & Digestive & Kidney Diseases (E.A.M.), National Institute on Aging and Veterans Administration (I.R.). |
Vol 119 - N° 8
P. 639-646 - août 2006 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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