Patent foramen ovale and obstructive sleep apnea: A new association? - 20/08/11

Doi : 10.1016/j.smrv.2010.02.002

Edmund M.T. Lau ^a,^b , Brendon J. Yee ^a,^b , Ronald R. Grunstein ^a,^b , David S. Celermajer ^c,^⁎
^a Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
^b Woolcock Institute of Medical Research, University of Sydney, 431 Glebe Point Road, Glebe NSW 2037, Australia
^c Department of Cardiology, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia

Corresponding author. Tel.: +612 9515 6519; fax: +612 9551 6262.

Summary

Patent foramen ovale (PFO) is a common congenital cardiac defect of the atrial septal wall affecting up to 25% of the population. PFO has received much clinical interest because it has been implicated in disease states such as stroke, migraine and decompression illness. More recently, there has been emerging evidence to support a clinically important relationship between PFO and obstructive sleep apnea (OSA). Furthermore, minimally invasive percutaneous techniques are now available for closure of PFO. We will review the current state of knowledge in the relationship between PFO and OSA, with emphasis on the pathophysiological interactions and clinical implications of this association.

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Keywords : Obstructive sleep apnea, Patent foramen ovale, Intracardiac shunting, Hypoxemia

Abbreviations : AHI, CPAP, ODI, OSA, PFO