Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood - 20/08/11
, Anna Bergström, PhD b, Erik Melén, MD, PhD b, d, Gunnar Lilja, PhD, MD c, Marianne van Hage, MD, PhD e, Göran Pershagen, PhD, MD a, b, Magnus Wickman, PhD, MD a, b, d
Reprint requests: Inger Kull, RN, PhD, Department of Occupational and Environmental Health, Norrbacka, SE-171 76 Stockholm, Sweden.Stockholm, Sweden
Abstract |
Background |
Early vitamin supplementation is given routinely to infants in many countries, but it is unclear whether this affects the risk of allergic diseases.
Objectives |
We sought to study the association between early-life supplementation of vitamins A and D in water-soluble form or in peanut oil and allergic diseases up to 4 years of age.
Methods |
A prospective birth cohort of 4089 newborn infants was followed for 4 years using parental questionnaires repeatedly to collect information on exposure and health. At 4 years, the response rate was 90%, and allergen-specific IgE levels to food and airborne allergens were measured in 2614 of the participating children.
Results |
Vitamins A and D were given to 98% of the children in infancy, and vitamins based in peanut oil dominated (90%). Children supplemented with vitamins A and D in water-soluble form during the first year of life had an almost 2-fold increased risk of asthma (adjusted odds ratio [OD], 2.18; 95% CI, 1.45-3.28), food hypersensitivity (adjusted OR, 1.89; 95% CI, 1.33-2.65), and sensitization to common food and airborne allergens (adjusted OR, 1.88; 95% CI, 1.34-2.64) at age 4 years compared with those receiving vitamins in peanut oil. No increased risk of IgE antibodies to peanut was seen in children receiving vitamins in peanut oil.
Conclusion |
Supplementation of vitamins A and D in water-soluble form seems to increase the risk of allergic disease up to the age of 4 years compared with supplementation with the same vitamins given in peanut oil.
Clinical implications |
Vitamins A and D in oil does not seem to increase the risk of allergic disease during childhood.
Le texte complet de cet article est disponible en PDF.Key words : Allergic disease, asthma, BAMSE, childhood, fatty acids, prevention, sensitization, vitamin D
Abbreviations used : BAMSE, OR
Plan
| Supported by the Swedish Asthma and Allergy Association, The Vardal Foundation for Health Care Sciences and Allergy Research, the Swedish Heart and Lung Foundation, and the Stockholm County Council. Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest. |
Vol 118 - N° 6
P. 1299-1304 - décembre 2006 Retour au numéro
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