The PTGDR gene is not associated with asthma in 3 ethnically diverse populations - 20/08/11
on behalf of the Genetics of Asthma in Latino Americans Study and the Study of African Americans, Asthma, Genes and Environments Investigators
Reprint requests: Esteban González Burchard, MD, Box 2911, Rock Hall 1550 4th St, SF 584C, University of California, San Francisco, San Francisco, CA 94143-2911.San Francisco and Oakland, Calif, Boston, Mass, San Juan, Puerto Rico, Mexico City, Mexico, and Chicago, Ill
Abstract |
Background |
The prostanoid DP receptor (PTGDR) gene on chromosome 14q22.1 has been identified as an asthma susceptibility gene. A haplotype with decreased transcription factor binding and transcription efficiency was associated with decreased asthma susceptibility in African American and white subjects. The significance of PTGDR gene variants in asthma has yet to be determined in Latinos, the largest US minority population, nor has the association been replicated in other populations.
Objective |
To determine the role of PTGDR gene variants in asthma susceptibility and asthma-related traits among the Mexican, Puerto Rican, and African American populations.
Methods |
We determined whether single nucleotide polymorphisms (SNPs) and haplotypes in PTGDR were associated with asthma and asthma-related traits by family-based and cross-sectional cohort analyses in 336 Puerto Rican and 273 Mexican asthmatic trios and by case-control analysis among African American subjects with asthma and healthy controls (n = 352).
Results |
We identified 13 SNPs in the PTGDR gene, and 6 were further analyzed. There was no significant association between PTGDR variants and asthma by family-based or case-control analyses. SNPs -441C and -197C and haplotype TTT showed marginal association with asthma-related traits in Mexican subjects. SNP -441 genotype TT (P = .05) and haplotype TTT (P = .02) were associated with increased IgE levels in African Americans.
Conclusion |
We conclude that the PTGDR gene is not a significant risk factor for asthma among Puerto Ricans, Mexicans, or African Americans.
Clinical implications |
Asthma candidate genes provide insights to pathophysiology and potentially new therapeutic targets, although the PTGDR gene was not found to be a significant risk factor for asthma in 3 populations.
Le texte complet de cet article est disponible en PDF.Key words : Asthma genetics, PTGDR gene, Latinos, African Americans
Abbreviations used : AIM, BMI, GALA, LD, MX, NY, PR, PTGDR, SAGE, SF, SNP, TDT
Plan
| Supported by National Institutes of Health (K23 HL04464, HL07185, GM61390, American Lung Association of California, Robert Wood Johnson Amos Medical Faculty Development Award, National Center on Minority Health and Health Disparities Scholar, Extramural Clinical Research Loan Repayment Program for Individuals from Disadvantaged Backgrounds, 2001-2003, to Dr Burchard HL51823, HL074204, 3M01RR000083-38S30488, HL56443, and HL51831 to the Asthma Clinical Research Network), SFGH General Clinical Research Center M01RR00083-41, U01-HL 65899, UCSF-Children’s Hospital of Oakland Pediatric Clinical Research Center (M01 RR01271), Oakland, Calif, Sandler Center for Basic Research in Asthma, and the Sandler Family Supporting Foundation. Dr Beckman was supported by National Institutes of Health grant P60 MD00222. Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest. |
Vol 118 - N° 6
P. 1242-1248 - décembre 2006 Retour au numéro
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