Mycobacterium africanum is not a major cause of human tuberculosis in Cape Town, South Africa - 20/08/11

Doi : 10.1016/j.tube.2010.02.004

Anne-Marie Demers ^a , Serge Mostowy ^b, David Coetzee ^c, Robin Warren ^d, Paul van Helden ^d, Marcel A. Behr ^b,^⁎
^a Département de Microbiologie et Immunologie, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada
^b Department of Medicine, McGill University, Montreal, QC, Canada
^c Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
^d DST/NRF Centre of Excellence for Biomedical TB Research, MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences – Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa

Corresponding author. Room A5.156, McGill University Health Centre1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada. Tel.: +1 514 394 1934x42815; fax: +1 514 934 8423.

Summary

While Mycobacterium africanum is an important cause of TB in several sites in West Africa, its distribution in other African countries is not well documented. In this study, conducted in Cape Town, 1175 isolates yielded 110 unique RFLP patterns; one of each of these 110 strains was tested for genomic deletions characteristic of M. africanum and other atypical members of the Mycobacterium tuberculosis complex. As none of these strains was marked by the deletion of RD9, we conclude that M. africanum and other atypical members of the M. tuberculosis complex are decidedly uncommon in this part of Africa.

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Keywords : Tuberculosis, Mycobacterium africanum, Genomic deletions, RFLP, Molecular epidemiology

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Vol 90 - N° 2

P. 143-144 - mars 2010 Retour au numéro

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Mycobacterium africanum is not a major cause of human tuberculosis in Cape Town, South Africa - 20/08/11

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