Epigallocatechin-3-gallate ameliorates hyperglycemia-induced embryonic vasculopathy and malformation by inhibition of Foxo3a activation - 19/08/11
Résumé |
Objective |
Maternal hyperglycemia increases the risk of congenital malformations. Epigallocatechin-3-gallate (EGCG), a natural antioxidant purified from green tea, inhibits oxidative stress signaling. We propose that EGCG prevents hyperglycemia-induced malformation via inhibition of oxidative stress signaling. The objective of this study is to examine the effect of EGCG on hyperglycemia-induced adverse effects during embryonic development.
Study Design |
Day-9 rat conceptuses were cultured under euglycemic (150 mg/dL glucose) and hyperglycemic (300 mg/dL glucose) conditions in the presence or absence of 1 or 10 μmol/L of EGCG.
Results |
Both 1 and 10 μmol/L of EGCG significantly ameliorated hyperglycemia-induced embryonic vasculopathy and malformations. Hyperglycemia inactivated protein kinase B (Akt) by reducing phosphorylated Akt levels. EGCG reversed the inhibitory effect of hyperglycemia on Akt activation. EGCG also prevented hyperglycemia-reduced phosphorylated Forkhead transcription factor 3a levels.
Conclusion |
EGCG prevented hyperglycemia-induced embryopathy through inhibition of Forkhead transcription factor 3a activation. This may have been mediated via the activation of Akt. These findings offer the potential for a possible pharmacological prophylaxis for hyperglycemia-induced embryonic malformations.
Le texte complet de cet article est disponible en PDF.Key words : Akt activation, epigallocatechin-3-gallate, Foxo3a activation, hyperglycemia, malformations, vasculopathy
Plan
| Cite this article as: Yang P, Li H. Epigallocatechin-3-gallate ameliorates hyperglycemia-induced embryonic vasculopathy and malformation by inhibition of Foxo3a activation. Am J Obstet Gynecol 2010;203:75.e1-6. |
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| Reprints not available from the authors. |
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| This research is supported by National Institutes of HealthR01 DK083243 to P.Y. Dr Yang is a Building Interdisciplinary Research Careers in Women's Health scholar supported by National Institutes of HealthK12HD043489 (principal investigator: Dr Patricia Langenberg). |
Vol 203 - N° 1
P. 75.e1-75.e6 - juillet 2010 Retour au numéro
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