Twin-twin transfusion syndrome: an ethics-based and evidence-based argument for clinical research - 19/08/11
Résumé |
Aspects of twin-twin transfusion syndrome (TTTS) diagnosis, treatment alternatives, and research opportunities were considered during a consensus conference that was held by the North American Fetal Therapy Network in 2009. A 3-member scientific consensus panel gathered data from expert conference presentations, postconference communications, and comprehensive scientific literature database searches to develop recommendations for TTTS diagnosis, therapy, and research. The panel recommends retaining the Quintero staging system until a superior system has been validated appropriately. It concludes that there is normative equipoise to justify the performance of randomized clinical trials to identify the optimal treatment strategy for mild TTTS. Recommendations for the design and conduct of clinical trials and observational studies are also provided.
Le texte complet de cet article est disponible en PDF.Key words : ethics, treatment, twin-twin transfusion syndrome
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| Authorship and contribution to the article is limited to the 3 authors indicated. There was no outside funding or technical assistance with the production of this article. |
Vol 203 - N° 1
P. 3-16 - juillet 2010 Retour au numéro
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