The Role of Reactive Oxygen Species and Oxidative Stress in Mediating Particulate Matter Injury - 19/08/11

Doi : 10.1016/j.coem.2006.07.005

Tian Xia, MD, PhD ^a,^b, Michael Kovochich, BS ^a,^b, Andre Nel, MD, PhD ^a,^b,^⁎
^a Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles, 52-175 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095-1680, USA
^b Southern California Particle Center, 650 Charles E. Young Drive South, Box 951772, Los Angeles, CA 90095-1772, USA

Corresponding author. Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles, 52-175 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095-1680.

Plan

Evidence that reactive oxygen species and oxidative stress are involved in particular matter–induced injury

Particle components, including absorbed particulate matter chemicals, are responsible for spontaneous particulate matter–induced reactive oxygen species production

Biologic mechanisms of particulate matter–induced reactive oxygen species generation

The biology of oxidative stress explains several particulate matter–induced adverse health effects

The importance of oxidative stress in future research and therapy for particulate matter–induced adverse health effects

Summary

Support for this article provided by US Public Health Service grants U19AI 070453 (UCLA Asthma and Allergic Disease Clinical Research Center), RO1 ES10553 (National Institute of Environmental and Health Science), RO1 ES15498, RO1 ES13432, and RO1 ES10253 and the US Environmental Protection Agency STAR award (RD-83241301) to the Southern California Particle Center and Supersite. This work has not been subjected to the Environmental Protection Agency for peer and policy review and does not necessarily reflect the views of the agency. No official endorsement should be inferred.