Does donor race still make a difference in deceased-donor African-American renal allograft recipients? - 19/08/11
Corresponding author. Tel.: + 1 313 745 7319; fax: + 1 313 993 0595Abstract |
Background |
Prior studies have demonstrated that African-American (AA) donor kidneys are independently associated with an increased risk for graft loss.
Methods |
We examined outcomes in comparable groups of AA deceased-donor (DD) kidney transplant patients receiving an AA donor (n = 35) versus a Caucasian donor (C group; n = 150) organ.
Results |
There were no differences between AA and C groups in patient survival, new-onset diabetes, or BK nephropathy. The AA group demonstrated a significantly higher 6-month and overall incidence of acute rejection (AR), increased cytomegalovirus (CMV) infection, and decreased graft survival. Recurrent or de novo focal segmental glomerulosclerosis (FSGS) accounted for a significantly higher fraction of graft losses in the AA versus C group.
Conclusions |
AA DD renal allograft recipients have equivalent patient but decreased graft survival when transplanted with an AA versus C kidney using current immunosuppression. This may be the result of increased AR, CMV infection, and recurrence/development of FSGS.
Le texte complet de cet article est disponible en PDF.Keywords : Donor race, Kidney transplantation, African American
Plan
Vol 199 - N° 3
P. 305-309 - mars 2010 Retour au numéro
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