Pro- and antiinflammatory cytokines in threatened miscarriages - 19/08/11
, Shanthi Muttukrishna, PhD, DSc c, Arnold R. Pizzey b, Eric Jauniaux, MD, PhD a
Reprints: Jean Calleja-Agius, MD, Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Tal-Qroqq, MSD 2080, MaltaRésumé |
Objective |
The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatened miscarriage (TM) and subsequent outcome.
Study Design |
Plasma levels of tumor necrosis factor (TNF)-receptors 1 and 2, TNF⍺, interferon gamma (IFNγ), and interleukins (IL) -6 and -10 were measured by flow cytometric bead assays in 80 women with TM: 53 women with normal outcome and 27 women who miscarried. Fluorescent antibody labeling was also performed on whole blood in a subgroup of 27 women of TM: 16 women with normal outcome and 11 women who miscarried.
Results |
Monocyte expression of TNF⍺ and circulating levels of TNF⍺, IFNγ, IL-10, IL-6, and TNF-R1 were significantly lower, whereas circulating levels of TNF⍺/IL-10, IFNγ/IL-10, and TNF⍺/IL-6 ratios were significantly higher, in women with TM who subsequently miscarried, compared with the women with normal outcome.
Conclusion |
An increased Th1 type of immune response, which was similar to that observed in preterm delivery, was found in TM cases that were complicated by a subsequent miscarriage.
Le texte complet de cet article est disponible en PDF.Key words : cytokine, interleukin-10, threatened miscarriage, TNF receptor, tumor necrosis factor
Plan
| Authorship and contribution to the article is limited to the 4 authors indicated. There was no outside funding or technical assistance with the production of this article. |
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| Cite this article as: Calleja-Agius J, Muttukrishna S, Pizzey AR, et al. Pro- and antiinflammatory cytokines in threatened miscarriages. Am J Obstet Gynecol 2011;205:83.e8-16. |
Vol 205 - N° 1
P. 83.e8-83.e16 - juillet 2011 Retour au numéro
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