Inflammatory cytokine and matrix metalloproteinase expression induced by collagen-coated and uncoated polypropylene meshes in a rat model - 19/08/11
Résumé |
Objective |
The objective of the study was to compare the influence of collagen-coated vs uncoated polypropylene meshes on the expression of genes critical for wound healing.
Study Design |
In 54 rats, abdominal wall defects were created, repaired by polypropylene sutures, and covered by an overlay of coated polypropylene (n = 20), uncoated polypropylene (n = 18), or no mesh (n = 16). Explants were harvested 7 or 90 days after repair and divided for histological, immunohistochemical, and messenger ribonucleic acid (mRNA) analyses. Real-time quantitative polymerase chain reaction arrays were used to profile the expression of 84 genes at the tissue-mesh interface.
Results |
One week after implantation, coated mesh elicited a slightly greater inflammatory response and increased mRNA expression of 4 proinflammatory cytokines compared with uncoated mesh. Both materials, however, induced a comparable expression of cytokines and matrix metalloproteinases relative to suture repair 90 days after implantation.
Conclusion |
Collagen-coated polypropylene mesh induces elevated inflammatory cytokine expression compared with uncoated mesh early in the healing process, but the response to both meshes is similar 90 days after implantation.
Le texte complet de cet article est disponible en PDF.Key words : coated polypropylene mesh, inflammatory cytokines, matrix metalloproteinases, pelvic organ prolapse, rat model
Plan
| Cite this article as: Pierce LM, Asarias JR, Nguyen PT, et al. Inflammatory cytokine and matrix metalloproteinase expression induced by collagen-coated and uncoated polypropylene meshes in a rat model. Am J Obstet Gynecol 2011;205:82.e1-9. |
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| Reprints not available from the authors. |
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| This study was supported in part by a Victoria S. and Bradley L. Geist Foundation grant (awarded to L.M.P.). |
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| The views expressed herein are those of the authors and do not reflect the official policy or position of the Department of the Army, the Department of Defense, or the US Government. |
Vol 205 - N° 1
P. 82.e1-82.e9 - juillet 2011 Retour au numéro
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