Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu - 19/08/11
, Katherine P. Himes, MD a, Raman Venkataramanan, PhD c, Lisa M. Bodnar, PhD a, b
Reprints: Hyagriv N. Simhan, MD, Magee Womens Hospital, Department of OB/GYN, 300 Halket St., Pittsburgh, PA 15213Résumé |
Objective |
We previously reported that elevated antiinflammatory cervical cytokines in early pregnancy were associated with spontaneous preterm birth. Our objective was to explore the relation between serum folate vitamers and the lower genital tract inflammatory milieu.
Study Design |
Pregnant women (n = 417) at <16 weeks' gestation had serum samples that were analyzed for folate species 5-methyltetrahydrofolate, 5-formyltetrahydrofolate, and cervical fluid that was assayed for cytokine concentrations. Patterns in proinflammatory cytokines (interleukin [IL]-1β, -6, -8, and -10; monocyte chemotactic protein-1) and antiinflammatory cytokines (IL-4, IL-10, IL-13) were identified with factor analysis.
Results |
After confounder adjustment, maternal serum 5-methyltetrahydrofolate concentrations had a strong negative association with elevated antiinflammatory scores; serum 5-formyltetrahydrofolate concentrations were associated positively with elevated antiinflammatory scores (both P < .05). Maternal folate was not associated with proinflammatory scores.
Conclusion |
Maternal serum folate vitamers are associated with cervical cytokine concentrations, which suggests a possible mechanistic link between folate and preterm birth risk.
Le texte complet de cet article est disponible en PDF.Key words : folate, cytokine, inflammation, preterm birth
Plan
| Supported by National Institutes of Health Grant nos. R01 HD041663 and R01 HD052732 (H.N.S.) and K01 MH074092 and R01 HD056999 (L.M.B.) and by Grant no. UL1 RR024153 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and the NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. Information on NCRR is available at www.ncrr.nih.gov/. |
|
| Cite this article as: Simhan HN, Himes KP, Venkataramanan R, et al. Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu. Am J Obstet Gynecol 2011;205:61.e1-7. |
Vol 205 - N° 1
P. 61.e1-61.e7 - juillet 2011 Retour au numéro
Article précédent
- Cervical collagen concentration within 15 months after delivery
- Iben Sundtoft, Steffen Sommer, Niels Uldbjerg
- Patients with cervical cancer: why did screening not prevent these cases?
- Roosmarie P. de Bie, Henke C. Vergers-Spooren, Leon F.A.G. Massuger, Albertus G. Siebers, Maria R.J. Salet-van der Pol, Judith E.M. Vedder, Willem J.G. Melchers, Johan Bulten, Ruud L.M. Bekkers
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?