Pregravid cardiometabolic risk profile and risk for gestational diabetes mellitus - 19/08/11
, Jeanne A. Darbinian, MPH, Charles P. Quesenberry, PhD, Assiamira Ferrara, MD
Reprints: Monique Hedderson, PhD, Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612–2304Résumé |
Objective |
The purpose of this study was to examine pregravid cardiometabolic profile and subsequent risk of gestational diabetes mellitus (GDM).
Study Design |
GDM cases (n = 199) and control subjects (n = 381) were selected from a cohort of women who took part in a multiphasic health checkup examination at Kaiser Permanente from 1984–1996 and who had a subsequent pregnancy and were matched by year and age at multiphasic health checkup examination and age at delivery.
Results |
Pregravid measurements of serum glucose levels of 100–140 mg/dL, body mass index of ≥25.0 kg/m2, and prehypertension/hypertension level were associated independently with GDM risk (odds ratios [OR], 4.8; 95% confidence interval [CI], 1.7–13.9; OR, 2.7; 95% CI, 1.6–4.3; and OR, 1.5; 95% CI, 1.0–2.3, respectively). The risk of GDM increased with the number of cardiometabolic risk factors (P < .001); adverse levels of both body mass index and glucose were associated with a 4.6-fold increased risk of GDM, compared with women with normal levels (P = .0001).
Conclusion |
Pregravid cardiometabolic risk profile may help clinicians to identify high-risk women to target for primary prevention or early management of GDM.
Le texte complet de cet article est disponible en PDF.Key words : cardiometabolic risk factor, gestational diabetes mellitus (GDM)
Plan
| Supported by a community benefit grant from Kaiser Permanente. |
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| Cite this article as: Hedderson MM, Darbinian JA, Quesenberry CP, et al. Pregravid cardiometabolic risk profile and risk for gestational diabetes mellitus. Am J Obstet Gynecol 2011;205:55.e1-7. |
Vol 205 - N° 1
P. 55.e1-55.e7 - juillet 2011 Retour au numéro
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