Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity - 19/08/11
, Jolande Y. Vis, MD, MSc b, Desiree A.P.M. Pattinaja, MD a, Rosanna A. Kuin b, Monique C. Stam, MD b, Janine M. Reuvers, MD b, Ben Willem J. Mol, MD, MSc, PhD a, b
Reprints: Femke Wilms, MD, Department of Obstetrics and Gynecology, Máxima Medical Center, PO 7777, 5500 MB Veldhoven, The NetherlandsRésumé |
Objective |
The purpose of this study was to assess the relationship between neonatal respiratory morbidity and the interval between antenatal corticosteroids (ACS) administration and birth.
Study Design |
We performed a retrospective cohort study among women who had received ACS and delivered at <34 weeks of gestation. We categorized these women in 4 groups: ACS-to-delivery interval of 0-7, 8-14, 15-21, and 22-28 days. Multivariable logistic regression analysis assessed the association between the ACS-to-delivery interval and neonatal respiratory morbidity.
Results |
We included 254 neonates. Eighty-two neonates (32%) were intubated. In comparison with neonates with an ACS-to-delivery interval of 0-7 days, the risk for intubation was increased in all other groups (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.1–5.4; OR, 5.6; 95% CI, 1.8–18; and OR, 4.8; 95% CI, 0.71–32, not statistically significant, respectively).
Conclusion |
The effect of ACS decreases when the ACS-to-delivery interval exceeds 7 days. The first administration of ACS should be considered carefully.
Le texte complet de cet article est disponible en PDF.Key words : corticosteroid, preterm delivery, respiratory morbidity
Plan
| Cite this article as: Wilms FF, Vis JY, Pattinaja DAPM, et al. Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity. Am J Obstet Gynecol 2011;205:49.e1-7. |
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| Authorship and contribution to the article is limited to the 7 authors indicated. There was no outside funding or technical assistance with the production of this article. |
Vol 205 - N° 1
P. 49.e1-49.e7 - juillet 2011 Retour au numéro
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