Systemic Markers of Inflammation, Endothelial Dysfunction, and Age-Related Maculopathy - 18/08/11
, Barbara E.K. Klein, MD, MPH a, Michael D. Knudtson, MS a, Tien Yin Wong, MD, PhD b, Anoop Shankar, MD, MPH a, Michael Y. Tsai, PhD c
Inquiries to Ronald Klein, MD, MPH, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 North Walnut Street, 460 WARF, Madison, WI 53726; fax: (608) 263-0279Résumé |
Purpose |
To examine the association of systemic markers of inflammatory disease and endothelial dysfunction with age-related maculopathy (ARM).
Design |
(1) Nested case-control analysis of prevalent ARM and (2) prospective analyses of incident ARM in a random sample of a population-based cohort.
Methods |
Standardized protocols for blood collection, measurement of markers, administration of a questionnaire, and gradings of stereoscopic color fundus photography to determine ARM were used. Standard univariate and multivariate analyses were performed. participants: Included in the nested case-control study were 188 cases with moderate to advanced ARM and 195 controls matched for age, gender, and current smoking status at a baseline examination from 1988 to 1990, and living in Beaver Dam, Wisconsin. Included in the prospective analyses as a random sample of 321 persons were those who participated in a 5-year and/or 10-year follow-up. main outcome measures: Prevalent and incident ARM.
Results |
Serum C-reactive protein, amyloid A, interleukin-6, tumor necrosis factor-⍺, intracellular adhesion molecule, E-selectin, folate, and Chlamydia pneumoniae IgG antibody were not associated with either prevalent or incident ARM.
Conclusion |
Contrary to other reports, we cannot confirm a strong or consistent relationship of markers of inflammation and endothelial dysfunction with ARM.
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| This study was supported by National Institutes of Health Bethesda, Maryland, grant no. EY06594 (R.K. and B.E.K.K.). |
Vol 140 - N° 1
P. 35.e1-35.e12 - juillet 2005 Retour au numéro
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