Using Optical Coherence Tomography to Monitor Photodynamic Therapy in Age Related Macular Degeneration - 18/08/11
, Alfredo García-Layana, MD, PhD, Miguel J. Maldonado, MD, PhD, Carmen Sainz-Gómez, MD, PhD, Aurora Alvárez-Vidal, MS
Inquiries to Angel Salinas-Alamán, MD, PhD, Departament of Ophthalmology, Clínica Universitaria de Navarra, Avda. Pío XII, 36, 31080 Pamplona, Spain; fax: 00-34-948-296500Résumé |
Purpose |
To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularization (CNV) activity before and after photodynamic therapy (PDT) in patients with age-related macular degeneration (ARMD).
Design |
Prospective observational case series.
Methods |
setting: Institutional study. patient population: Fifty-three patients (62 eyes) with ARMD. observation procedure: Prospective observational case study. main outcome measures: Presence or absence of leakage on fluorescein angiography, presence of intraretinal or sub-retinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT.
Results |
The macular thickness decreased significantly after PDT (P = .001). However, no significant changes in CNV thickness were measured after PDT (P = .567). Once the diagnosis of ARMD was established before treatment, OCT had a sensitivity of 96.77% for detecting CNV activity. After treatment, OCT had a good sensitivity (95.65%) and a moderate specificity (59.01%) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 82.95%.
Conclusions |
OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with ARMD.
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Vol 140 - N° 1
P. 23.e1-23.e7 - juillet 2005 Retour au numéro
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