Frailty and Age-related Macular Degeneration: The Beaver Dam Eye Study - 18/08/11
, Barbara E.K. Klein, MD, MPH, Michael D. Knudtson, MS
Inquiries to Ronald Klein, MD, MPH, University of Wisconsin Medical School, Room 405 WARF, 610 N Walnut Street, Madison, WI 53726; fax: (608) 263-0279Résumé |
Purpose |
To investigate the associations of measures of frailty to prevalent age-related maculopathy (ARM).
Design |
Cross-sectional population-based study.
Methods |
Time to walk a measured course (gait-time), handgrip strength, peak expiratory flow rate, ability to stand from a sitting position without using arms, self-reported co-morbidities, and ARM were assessed at the third examination of the Beaver Dam Eye Study (n = 2,962). ARM was determined by grading stereoscopic color fundus photographs.
Results |
While controlling for age, smoking, and the number of co-morbid conditions, weaker handgrip strength was associated with early ARM (odds ratio [OR]/10 kg decrease 1.28, confidence interval [CI] 1.08, 1.52, P = .004) and late ARM (OR 1.55, 95% CI 1.02, 2.36) in men but not women. Other measures of frailty were not related to ARM.
Conclusions |
A weak cross-sectional association of handgrip strength with ARM (in men) was found after controlling for co-morbid conditions. These data suggest that ARM is due to a specific disease process, albeit age-related, rather than to biologic aging, as reflected by measures of frailty.
Le texte complet de cet article est disponible en PDF.
Vol 140 - N° 1
P. 129-131 - juillet 2005 Retour au numéro
Article précédent
- Visual Dysfunction After Panretinal Photocoagulation in Patients With Severe Diabetic Retinopathy and Good Vision
- David J. Browning
- Intraocular Pressure Over the Clinical Range of Blood Pressure: Blue Mountains Eye Study Findings
- Paul Mitchell, Anne J. Lee, Jie Jin Wang, Elena Rochtchina
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?