Disease Course of Patients With Pericentral Retinitis Pigmentosa - 18/08/11
, Alexander R. Gaudio, MD, Eliot L. Berson, MD
Inquires to Michael A. Sandberg, PhD, Berman-Gund Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114; fax: 617-573-3216Résumé |
Purpose |
To estimate the mean rates of decline of ocular function in patients with an atypical form of retinitis pigmentosa, termed “pericentral retinitis pigmentosa.”
Design |
Retrospective observational study.
Methods |
setting: Single-center. patient population: Eighteen patients (ages 32 to 65 years) with pericentral retinitis pigmentosa followed for 3 to 26 years. observational procedures: Snellen visual acuity, Goldmann visual field area (V-4e white test light), and full-field electroretinogram (ERG) amplitudes (0.5 Hz and 30 Hz white flashes). main outcome measures: Mean annual exponential rates of change quantified by repeated-measures longitudinal regression.
Results |
Estimated mean annual rates of decline of remaining ocular function were 1.2% for visual acuity, 1.9% for visual field area, 2.5% for ERG amplitude to 0.5 Hz flashes, and 2.9% for ERG amplitude to 30 Hz flashes.
Conclusions |
The mean rates of loss of remaining ocular function of patients with pericentral retinitis pigmentosa were generally slower than those previously reported for patients with typical forms of retinitis pigmentosa.
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| Sponsored by National Institutes of Health grant EY00169, the Foundation Fighting Blindness, Owings Mills, MD, and the Massachusetts Lions Eye Research Fund, Inc. |
Vol 140 - N° 1
P. 100.e1-100.e8 - juillet 2005 Retour au numéro
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