Topical Interferon Alfa-2b for the Treatment of Recalcitrant Ocular Surface Squamous Neoplasia - 18/08/11
Résumé |
Purpose |
To evaluate topical interferon alfa-2b (IFN-⍺2b) for the treatment of recalcitrant ocular surface squamous neoplasia (OSSN).
Design |
Prospective, noncomparative, interventional consecutive case series.
Methods |
Ten patients with recalcitrant OSSN were treated with topical IFN-⍺2b (1 million IU/ml) four times a day until clinical resolution of the lesion or until the lesion appeared nonresponsive—that is, treatment failure. Progress was assessed by clinical examination and photographic records, with a minimum follow-up of six months.
Results |
Eight of 10 patients achieved clinical resolution from topical IFN-⍺2b treatment. One patient developed invasive squamous cell carcinoma and underwent exenteration. The other patient required further mitomycin C therapy to achieve clinical resolution. The mean duration to clinical resolution for the eight patients treated with IFN-⍺2b was 21.9 weeks (range six to 59 weeks). There have been no recurrences for any of the nine patients during follow-up (mean 55.0 weeks; range 26 to 84 weeks).
Conclusions |
Topical IFN-⍺2b is an important treatment modality for recalcitrant OSSN; it avoids the risks of further limbal stem cell destruction from other agents and surgical excision. If invasive disease is diagnosed at any stage, topical therapy is contraindicated, necessitating surgical excision.
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Vol 142 - N° 4
P. 568 - octobre 2006 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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