Margin width as the sole determinant of local recurrence after breast conservation in patients with ductal carcinoma in situ of the breast - 18/08/11
, Melvin J. Silverstein, M.D., Laura A. Lee, M.D., Wei Ye, Ph.D., Premal Sanghavi, M.D., Dennis R. Holmes, M.D., Howard Silberman, M.D., Michael Lagios, M.D.
Corresponding author. Tel.: +1-323-865-3535; fax: +1-323-865-3539.Abstract |
Background |
A previous study showed a 3% local recurrence risk at 8 years in ductal carcinoma in situ (DCIS) patients treated with excision alone with surgical margins of 10 mm or greater. This study updates those data.
Methods |
A total of 272 DCIS patients treated conservatively with 10 mm or greater margins were reviewed in a prospective database.
Results |
Among 212 excision-alone patients, there were 9 DCIS and 3 invasive recurrences. The 12-year probability of any local recurrence was 13.9%; of invasive recurrence it was 3.4%. Among 60 excision plus radiation patients, there was 1 local (invasive) recurrence (P = .06). The 12-year probability of local recurrence was 2.5%.
Conclusions |
Local recurrence in DCIS patients treated with excision alone with margins of 10 mm or greater compares favorably with local recurrence in DCIS patients with nontransected margins and treated with postoperative radiation. The risk of invasive recurrence among widely excised DCIS patients is extremely low.
Le texte complet de cet article est disponible en PDF.Keywords : Ductal carcinoma in situ (DCIS), Breast cancer, Margin width, Local recurrence
Plan
Vol 192 - N° 4
P. 420-422 - octobre 2006 Retour au numéro
Article précédent
- Breast cancer–specific mortality after invasive local recurrence in patients with ductal carcinoma-in-situ of the breast
- Laura A. Lee, Melvin J. Silverstein, Cathie T. Chung, Heather Macdonald, Premal Sanghavi, Melinda Epstein, Dennis R. Holmes, Howard Silberman, Wei Ye, Michael D. Lagios
- Intraoperative injection of technetium-99m sulfur colloid is effective in the detection of sentinel lymph nodes in breast cancer
- Christine E. Dauphine, Iraj Khalkhali, M. Perla Vargas, Nova M. Isaac, Jason Haukoos, Hernan I. Vargas
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?