Breast cancer–specific mortality after invasive local recurrence in patients with ductal carcinoma-in-situ of the breast - 18/08/11
, Melvin J. Silverstein, M.D. a, Cathie T. Chung, M.D. a, Heather Macdonald, M.D. a, Premal Sanghavi, M.D. a, Melinda Epstein, Ph.D. a, Dennis R. Holmes, M.D. a, Howard Silberman, M.D. a, Wei Ye, Ph.D. a, Michael D. Lagios, M.D. b
Corresponding author. USC Norris Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave., Room 7415, Los Angeles, CA 90033-0800. Tel.: +1-323-865-3535; fax: +1-323-865-3539.Abstract |
Background |
Previous studies on the efficacy of primary treatments for ductal carcinoma-in-situ (DCIS) have focused on local recurrence rates. Our objective was to detail the outcomes of local invasive recurrence, distant recurrence, and breast cancer mortality in patients previously treated for DCIS.
Methods |
Clinical, pathologic, and outcome data were collected prospectively for 1236 patients with pure DCIS accrued from 1972 through 2005.
Results |
There were 150 recurrences (87 DCIS and 63 invasive). Invasive local recurrence after mastectomy was rare (0.5% of patients) and after breast preservation was more frequent (12.0% of patients). The 12-year probabilities of breast cancer-specific mortality after mastectomy and after breast preservation were 0.8% and 1.0%, respectively. The 12-year breast cancer-specific mortality and distant disease probability for the 63 patients with invasive recurrences were 12% and 15%, respectively.
Conclusions |
Regardless of initial treatment, most patients with invasive local recurrence after treatment for DCIS can be treated and cured.
Le texte complet de cet article est disponible en PDF.Keywords : Ductal carcinoma-in-situ, DCIS, Local recurrence, Breast cancer mortality
Plan
Vol 192 - N° 4
P. 416-419 - octobre 2006 Retour au numéro
Article précédent
- Compassion and communication in cancer care
- Edgar D. Staren
- Margin width as the sole determinant of local recurrence after breast conservation in patients with ductal carcinoma in situ of the breast
- Heather R. Macdonald, Melvin J. Silverstein, Laura A. Lee, Wei Ye, Premal Sanghavi, Dennis R. Holmes, Howard Silberman, Michael Lagios
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