Indications of partial hepatectomy for transplantable hepatocellular carcinoma with compensated cirrhosis - 18/08/11
Abstract |
Background |
The appropriate treatment strategy for transplantable hepatocellular carcinoma (HCC) patients with compensated cirrhosis remains controversial.
Methods |
Surgical outcomes were reviewed in 136 cirrhotic patients with transplantable HCC who had undergone partial hepatectomy. Transplantable HCC was defined as that corresponding to Milan’s criteria.
Results |
The adverse prognostic factors for both survival and disease-free survival were histologic surgical margin of 5 mm or less, Child-Pugh B, and the presence of hepatitis C virus infection. The overall 5-year survival and disease-free survival rates of patients with 1 or none of the adverse prognostic factors were 73% and 33%, respectively, whereas those of patients with 2 or 3 adverse prognostic factors were 36% and 17%, respectively.
Conclusions |
Transplantable HCC patients with 2 or 3 adverse prognostic factors should be considered candidates for liver transplantation, whereas patients with only 1 or none of the adverse prognostic factors are good candidates for partial hepatectomy.
Le texte complet de cet article est disponible en PDF.Keywords : Hepatocellular carcinoma, Hepatectomy, Cirrhosis, Liver transplantation, Milan’s criteria
Plan
Vol 189 - N° 2
P. 167-172 - février 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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