WHI clinical trial revisit: Imprecise scientific methodology disqualifies the study’s outcomes - 18/08/11
, Katarzyna M. Ostrzenska, MD b
Reprint requests: Adam Ostrzenski, MD, PhD, 14808 Gulf Blvd, Madeira Beach, FL 33708.Abstract |
We analyzed The Women’s Health Initiative (WHI) Study because it had a significant impact on clinical practice, both nationally and internationally. However, despite the widespread public and professional awareness of the results, an independent, nonbiased analysis of the quality of the methodology of the study has not been available. We find the study design and its execution question the validity of the results, making it difficult to apply the WHI results to healthy postmenopausal women, different ethnic groups, or as general postmenopausal prevention.
Le texte complet de cet article est disponible en PDF.Key words : Menopause, Hormone replacement therapy, Prempro, Estrogen replacement therapy, Women’s Health Initiative Study
Plan
Vol 193 - N° 5
P. 1599-1604 - novembre 2005 Retour au numéro
Article précédent
- Dexamethasone treatment does not improve the outcome of women with HELLP syndrome: A double-blind, placebo-controlled, randomized clinical trial
- Javier E. Fonseca, Fabián Méndez, Claudia Cataño, Fernando Arias
- WHI response to Ostrzenski and Ostrzenska
- Barbara B. Cochrane, David H. Barad, Margery Gass, Robert L. Brunner, Cora E. Lewis, Marcia L. Stefanick
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