Clinical and diagnostic significance of preoperative computed tomography findings of ascites in patients with advanced gastric cancer - 18/08/11
, Manabu Ohashi, M.D. a, Toshifumi Wakai, M.D. a, Satoru Nakagawa, M.D. a, Ryuta Sasamoto, M.D. b, Katsuyoshi Hatakeyama, M.D., Ph.D., F.A.C.S. b
Corresponding author. Tel.: +81-25-227-2228; fax: +81-25-227-0779.Abstract |
Background |
The relationship between ascites, as detected by preoperative computed tomography (CT), and peritoneal metastasis of gastric cancer requires clarification because of its likely significance for clinical outcome.
Methods |
A retrospective analysis of 293 patients with advanced gastric cancer investigated the association between preoperative CT findings of ascites and surgical findings of peritoneal washing cytology and peritoneal metastasis.
Results |
Forty-five of 293 patients (15%) presented with ascites on preoperative CT. Positive ascites on CT predicted the presence of free tumor cells with 40% sensitivity and 97% specificity, and peritoneal metastasis with 51% sensitivity and 97% specificity. Ascites on CT was an independent prognostic factor by univariate (P < .001) and multivariate (relative risk, 2.03; 95% confidence interval, 1.39–2.96; P < .001) analyses. The median survival time was 6.0 months in patients with positive ascites on CT.
Conclusions |
The presence of ascites on CT suggests the presence of peritoneal metastasis and indicates a poor prognosis. The presence of peritoneal metastasis should be confirmed by diagnostic laparoscopy in gastric cancer patients with ascites.
Le texte complet de cet article est disponible en PDF.Keywords : Gastric cancer, Ascites, Computed tomography, Peritoneal metastasis
Plan
Vol 192 - N° 2
P. 185-190 - août 2006 Retour au numéro
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