Does early EBV infection protect against IgE sensitization? - 18/08/11
, Annika Linde, MD, PhD b, Scott M. Montgomery, BSc, PhD c, Liselotte Gustafsson b, Per Näsman, Ph Lic d, Marita Troye Blomberg, PhD e, Gunnar Lilja, MD, PhD a
Reprint requests: Caroline Nilsson, MD, Department of Pediatrics, Sachs' Children's Hospital, Stockholm South Hospital, S-118 83 Stockholm, Sweden.Stockholm, Sweden
Abstract |
Background |
There is indirect evidence that an increased infectious burden is associated with a decreased prevalence of IgE-mediated allergy during childhood.
Objective |
To determine whether there is a relation between the serostatus of 13 different viruses and parentally reported infections and IgE sensitization in 2-year-old children. To investigate whether there is an interaction between cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in relation to IgE sensitization.
Methods |
A total of 246 infants were followed prospectively to 2 years of age with clinical examinations, skin prick test, and specific IgE analyses and through analysis of seropositivity against adenovirus, influenza, parainfluenza, respiratory syncytial virus, CMV, EBV, herpes simplex virus, human herpesvirus 6, and varicella-zoster virus.
Results |
There was some evidence that IgE sensitization (24%) tended to be more common among children who were seropositive against few compared with children who were seropositive against many viruses, but this was not statistically significant, and there was no consistent trend across the groups. IgE sensitization was statistically significantly less prevalent at 2 years of age among infants who were seropositive against EBV but not other viruses (adjusted odds ratio, 0.34; 95% CI, 0.14-0.86). The interaction of seropositivity against both CMV and EBV antibodies indicated a further reduction in the risk for IgE sensitization (adjusted odds ratio for interaction, 0.10; 95% CI, 0.01-0.92), indicating effect modification associated with seropositivity against CMV.
Conclusion |
Our results indicate that acquisition of EBV infection during the first 2 years of life is associated with a reduced risk of IgE sensitization, and this effect is enhanced by CMV coinfection.
Le texte complet de cet article est disponible en PDF.Key words : Childhood, CMV, EBV, IgE, infections, sensitization, serology, viral infections
Abbreviations used : EBV, CMV, HHV6, HSV, kUA, RSV, SPT, VZV
Plan
| Disclosure of potential conflict of interest: None to disclose. Supported by the Swedish Asthma and Allergy Association, Consul Th C Berg's Foundation, the Samariten Foundation, Mjölkdroppen, the Vårdal Foundation, the Heart and Lung Foundation, GlaxoSmithKline, Brio AB, and the Karolinska Institute. Pharmacia Diagnostics AB supplied reagents for plasma IgE analyses. |
Vol 116 - N° 2
P. 438-444 - août 2005 Retour au numéro
Article précédent
- Infant home endotoxin is associated with reduced allergen-stimulated lymphocyte proliferation and IL-13 production in childhood
- Joseph H. Abraham, Patricia W. Finn, Donald K. Milton, Louise M. Ryan, David L. Perkins, Diane R. Gold
- Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis
- Heather A. Coker, Helen E. Harries, Graham K. Banfield, Victoria A. Carr, Stephen R. Durham, Elfy Chevretton, Paul Hobby, Brian J. Sutton, Hannah J. Gould
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?