Perspectives on the past decade of asthma genetics - 18/08/11
Reprint requests: Carole Ober, PhD, Department of Human Genetics, The University of Chicago, 920 East 58th St, CLSC 507C, Chicago, IL 60637-1463.Chicago, Ill
Abstract |
Although genetic linkage and association studies have identified more than 25 asthma or allergy susceptibility loci, replication of significant results remains a problem. Moreover, these approaches typically ignore the true complexity of these diseases, such as the role of gene-by-environment and gene-by-gene interactions. As a result, many important associations might have been missed. Recent studies demonstrate not only that such interactions exist but also that the relationship between genotype and phenotype is more complex than previously thought.
Le texte complet de cet article est disponible en PDF.Key words : Asthma, allergy, genetics, gene-by-environment interactions
Abbreviations used : AD, ADRB2, CD14, COAST, FCERB1, GSTM1, GSTP1, HLAG, IL4RA, LTA, LTC4A, NOS3, TIM1, TLR4
Plan
| Guest editor: William W. Busse, MD |
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| Supported in part by National Institutes of Health grants HL56399, HL66533, HL70831, and HL72414. Disclosure of potential conflict of interest: All authors—none disclosed. |
Vol 116 - N° 2
P. 274-278 - août 2005 Retour au numéro
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