ADAM33: A Newly Identified Gene in the Pathogenesis of Asthma - 18/08/11
Doi : 10.1016/j.iac.2005.07.003
Stephen T. Holgate, MD, DSc, FRCP, FMedSci ⁎ 
, Donna E. Davies, PhD, Rob M. Powell, PhD, John W. Holloway, PhD
, Donna E. Davies, PhD, Rob M. Powell, PhD, John W. Holloway, PhD Infection, Inflammation, and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, Hampshire, SO16 6YD, UK
⁎Corresponding author. Southampton General Hospital, Mail Point 810, Level F, Pathology and Laboratory Block, Southampton SO16 6YD, UK
Résumé |
Asthma has a high heritability of up to 75%, involving a few genes with moderate effects rather than many genes with small effects. Two methods most frequently used to search for disease-causing genes are the candidate gene approach and positional cloning (reverse genetics). Recent work has provided validation of ADAM33 as an asthma susceptibility gene by replicating the association.
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© 2005
Elsevier Inc. Tous droits réservés.
Vol 25 - N° 4
P. 655-668 - novembre 2005 Retour au numéro
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